Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466189 | 0.92 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL6583028 | 0.92 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL6176379 | 0.91 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7894289 | 0.89 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL6971499 | 0.89 | EDNRA (0.61) | EDNRAEDNRB | |
| SCHEMBL5035143 | 0.88 | EDNRA (0.79) | EDNRAEDNRB | |
| Avosentan SCHEMBL29379732 | 0.86 | EDNRA (1.00) | EDNRAEDNRB | |
| Avosentan SCHEMBL2742679 | 0.86 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL5036194 | 0.86 | EDNRA (0.77) | EDNRAEDNRB | |
| SCHEMBL5035167 | 0.86 | EDNRA (0.77) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149091-B1 | 4-(HETEROCYCLYLSULFONAMIDO)-5-METHOXY-6-(2-METHOXYPHENOXY)-2-PHENYL- OR PYRIDYLPYRIMIDINES AS ENDOTHELIN RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | claimed |