Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.48 |
| ▸ | PPARG | P37231 | 10/20 | 0.48 |
| ▸ | PPARD | Q03181 | 6/20 | 0.48 |
| ▸ | PDE5A | O76074 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6426198 | 0.88 | PPARA (0.62) | PPARAPPARGPPARDMEN1KMT2A | |
| SCHEMBL5034531 | 0.88 | PPARA (0.41) | PPARAPPARGPPARDPDE5AMEN1 | |
| SCHEMBL5031836 | 0.88 | PDE4A (0.43) | PPARAPPARGPPARDPDE5ALMNA | |
| SCHEMBL6888818 | 0.87 | HTT (0.43) | PPARAPPARGPPARDPDE5AMEN1 | |
| SCHEMBL6426963 | 0.85 | PPARA (0.44) | PPARAPPARGPPARDPDE5ALMNA | |
| SCHEMBL5029881 | 0.84 | PPARA (0.40) | PPARAPPARGPPARDPDE5ALMNA | |
| SCHEMBL5029907 | 0.84 | PPARA (0.40) | PPARAPPARGPPARDPDE5ALMNA | |
| SCHEMBL5031792 | 0.83 | PPARA (0.39) | PPARAPPARGPPARDPDE5A | |
| SCHEMBL5032845 | 0.82 | PPARA (0.46) | PPARAPPARGPPARDLMNA | |
| SCHEMBL5030048 | 0.80 | PDE4A (0.37) | PPARAPPARGPPARDHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371777-B2 | Cyclic compound and PPAR agonist | EISAI CO., LTD. (JP) | 2008-05-13 | — | — | US | disclosed |
| US-7371777-B2 | Cyclic compound and PPAR agonist | EISAI CO., LTD. (JP) | 2008-05-13 | — | — | US | disclosed |
| US-7371777-B2 | Cyclic compound and PPAR agonist | EISAI CO., LTD. (JP) | 2008-05-13 | — | — | US | disclosed |