Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 5/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL2085061 | 0.90 | BACE1 (0.43) | BACE1KCNH2CTSDBACE2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2085131 | 0.89 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2085705 | 0.86 | BACE1 (0.45) | BACE1KCNH2CTSDBACE2 | |
| Trifluoroacetic Acid SCHEMBL2083989 | 0.85 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2 | |
| Trifluoroacetic Acid SCHEMBL2084782 | 0.85 | BACE1 (0.42) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL2085133 | 0.85 | BACE1 (0.37) | BACE1KCNH2CTSDBACE2DHFR | |
| SCHEMBL3549986 | 0.82 | BACE1 (0.42) | BACE1KCNH2CTSDBACE2 | |
| Trifluoroacetic Acid SCHEMBL2085456 | 0.82 | BACE1 (0.45) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL3554052 | 0.81 | BACE1 (0.48) | BACE1KCNH2CTSDBACE2 | |
| Trifluoroacetic Acid SCHEMBL2086215 | 0.80 | BACE1 (0.58) | BACE1KCNH2CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171771-A1 | New Compounds 391 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171771-A1 | New Compounds 391 | PSEN2, PSEN1, MAPT | BACE1 4/4885KCNH2 2710/4885CTSD 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.