⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038721 | 1.00 | — | — | |
| SCHEMBL82013 | 0.69 | — | — | |
| SCHEMBL10394965 | 0.69 | — | — | |
| SCHEMBL230705 | 0.67 | — | — | |
| Thiourea SCHEMBL8845816 | 0.67 | TSHR (0.38) | — | |
| SCHEMBL14255574 | 0.64 | — | — | |
| SCHEMBL16770631 | 0.64 | — | — | |
| SCHEMBL12126853 | 0.64 | — | — | |
| SCHEMBL9530148 | 0.63 | — | — | |
| SCHEMBL24385243 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108602-B | Process for preparing thiazole derivatives | 协和麒麟株式会社 | 2021-08-03 | — | — | CN | disclosed |
| EP-3242877-A1 | PRODUCTION METHOD OF THIAZOLE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2017-11-15 | — | — | EP | disclosed |
| CN-107108602-A | The preparation method of thiazole | 协和发酵麒麟株式会社 | 2017-08-29 | — | — | CN | disclosed |
| WO-2016111381-A1 | PRODUCTION METHOD OF THIAZOLE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2016-07-14 | — | — | WO | disclosed |
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |
| EP-1694673-A1 | NOVEL THIAZOLE DERIVATES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-30 | — | — | EP | disclosed |
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
| WO-2005058887-A1 | NOVEL THIAZOLE DERIVATES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
| WO-1996005187-A1 | (4-(3-AMINOMETHYLPHENYL)THIAZOL-2-YL)-GUANIDINES AS H2-RECEPTOR ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-22 | — | — | WO | disclosed |