Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A3 | P38919 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176116 | 1.00 | EIF4A3 (0.47) | EIF4A3CHRNA7HTR3ACNR1CNR2 | |
| Hydrochloric Acid SCHEMBL1175574 | 0.99 | EIF4A3 (0.47) | EIF4A3CHRNA7HTR3ACNR1CNR2 | |
| SCHEMBL1176110 | 0.89 | EIF4A3 (0.47) | EIF4A3CHRNA7HTR3ACNR1CNR2 | |
| Hydrochloric Acid SCHEMBL1175794 | 0.88 | EIF4A3 (0.46) | EIF4A3CHRNA7HTR3ACNR1CNR2 | |
| SCHEMBL1385917 | 0.85 | HRH4 (0.42) | EIF4A3RBP4MAPTCHRNB2CHRNA3 | |
| SCHEMBL5046315 | 0.85 | IDO1 (0.45) | EIF4A3RBP4CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL2600879 | 0.85 | IDO1 (0.45) | EIF4A3RBP4CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL5043665 | 0.85 | HRH4 (0.42) | EIF4A3RBP4MAPTCHRNB2CHRNA3 | |
| Hydrochloric Acid SCHEMBL1176083 | 0.84 | IDO1 (0.44) | EIF4A3RBP4CHRNB2CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL1176347 | 0.84 | HRH4 (0.41) | EIF4A3RBP4MAPTCHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |