Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039286 | 0.84 | GRM5 (0.50) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL4421873 | 0.81 | GRM5 (0.55) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL4431219 | 0.81 | GRM5 (0.44) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL30558432 | 0.80 | GRM5 (0.57) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL5039087 | 0.80 | GRM5 (0.57) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL4432311 | 0.80 | NPC1 (0.44) | GRM5KDM4EHPGDALDH1A1LMNA | |
| SCHEMBL15070177 | 0.75 | GRM5 (0.48) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL5035590 | 0.73 | GRM5 (0.51) | GRM5KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL8246660 | 0.73 | GRM5 (0.51) | GRM5KDM4EHPGDMAOAMAOB | |
| SCHEMBL4421928 | 0.73 | KDM4E (0.47) | GRM5KDM4EHPGDMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | claimed |
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | disclosed |