SCHEMBL5040304

SCHEMBL5040304

CCOc1ccc2c(n1)CC(C)(C)CC2=O

nearest known ligand 0.70

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.59
ALDH1A1 P00352 10/20 0.53
HTT P42858 1/20 0.53
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
MAOA P21397 2/20 0.44
MAOB P27338 2/20 0.44
GAA P10253 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
GRM5 P41594 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.42
TSHR P16473 1/20 0.42
KMT2A Q03164 1/20 0.42
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4421435 0.85 CYP2C19 (0.55) CYP2C19ALDH1A1HTTNPC1RAB9A
Hydrochloric Acid SCHEMBL4424652 0.83 CYP2C19 (0.54) CYP2C19ALDH1A1HTTNPC1RAB9A
SCHEMBL4426163 0.82 CYP2C19 (0.52) CYP2C19ALDH1A1HTTMAOAMAOB
Hydrochloric Acid SCHEMBL4432540 0.81 CYP2C19 (0.51) CYP2C19ALDH1A1HTTMAOAMAOB
SCHEMBL4423838 0.81 CYP2C19 (0.38) CYP2C19ALDH1A1HTTNPC1RAB9A
SCHEMBL14087697 0.77 CYP2C19 (0.46) CYP2C19ALDH1A1HTTNPC1RAB9A
SCHEMBL4426496 0.76 GRM5 (0.44) HTTNPC1RAB9AMAOAMAOB
SCHEMBL4423630 0.75 CYP2C19 (0.54) CYP2C19ALDH1A1HTTMAOAMAOB
SCHEMBL25717168 0.74 CYP2C19 (1.00) CYP2C19ALDH1A1HTTNPC1RAB9A
Hydrochloric Acid SCHEMBL4433084 0.74 CYP2C19 (0.52) CYP2C19ALDH1A1HTTMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1723116-B1 TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS MERZ PHARMA GMBH & CO KGAA (DE) 2008-09-24 EP claimed
EP-1723116-B1 TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS MERZ PHARMA GMBH & CO KGAA (DE) 2008-09-24 EP disclosed