Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 16/20 | 0.67 |
| ▸ | CX3CR1 | P49238 | 11/20 | 0.67 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842337 | 0.88 | CXCR2 (0.68) | CXCR2CX3CR1HTR1BPAK4 | |
| SCHEMBL841953 | 0.81 | CXCR2 (0.98) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842205 | 0.81 | CXCR2 (0.86) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841943 | 0.80 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841944 | 0.80 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B | |
| SCHEMBL6704358 | 0.80 | CXCR2 (0.80) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842338 | 0.80 | CXCR2 (0.88) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841954 | 0.79 | CXCR2 (0.98) | CXCR2CX3CR1HTR1B | |
| SCHEMBL842206 | 0.79 | CXCR2 (0.86) | CXCR2CX3CR1HTR1B | |
| SCHEMBL841882 | 0.78 | CXCR2 (1.00) | CXCR2CX3CR1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1348709-B1 | Thiazolo[4,5-d]pyrimidine compounds for the treatment of rheumatoid arthritis | ASTRAZENECA UK LTD (GB) | 2008-01-16 | — | — | EP | claimed |