Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | MUSK | O15146 | 1/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5041147 | 0.84 | AURKA (0.74) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL4286999 | 0.81 | AURKA (1.00) | AURKAAURKB | |
| SCHEMBL3490681 | 0.80 | AURKA (0.71) | AURKAAURKBKDR | |
| SCHEMBL5495302 | 0.79 | AURKA (0.59) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5487200 | 0.79 | AURKA (0.76) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL3489346 | 0.78 | AURKA (0.90) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL6525975 | 0.78 | AURKA (0.90) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5488372 | 0.77 | AURKA (0.86) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL5494428 | 0.77 | AURKA (0.86) | AURKAAURKBPLK4CITMUSK | |
| SCHEMBL3490173 | 0.77 | AURKA (1.00) | AURKAAURKBPLK4CITMUSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402585-B2 | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2008-07-22 | — | — | US | disclosed |