Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 13/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | F7 | P08709 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5042318 | 0.99 | F10 (0.45) | F10ST14F2MASP2PRSS1 | |
| SCHEMBL5037908 | 0.93 | F2 (0.45) | F10ST14F2MASP2PRSS1 | |
| Acetic Acid SCHEMBL5042397 | 0.91 | KDM4E (0.42) | F10ST14F2MASP2PRSS1 | |
| SCHEMBL5047696 | 0.90 | ST14 (0.43) | F10ST14F2MASP2PRSS1 | |
| SCHEMBL5044971 | 0.90 | ST14 (0.46) | F10ST14F2MASP2PRSS1 | |
| SCHEMBL5044974 | 0.90 | ST14 (0.46) | F10ST14F2MASP2PRSS1 | |
| Hydrochloric Acid SCHEMBL5045151 | 0.90 | ST14 (0.42) | F10ST14F2MASP2PRSS1 | |
| Hydrochloric Acid SCHEMBL5047665 | 0.89 | CARM1 (0.46) | F10ST14F2MASP2PRSS1 | |
| Hydrochloric Acid SCHEMBL5047660 | 0.89 | CARM1 (0.46) | F10ST14F2MASP2PRSS1 | |
| SCHEMBL6448878 | 0.89 | ST14 (0.50) | F10ST14F2MASP2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567498-B1 | MANDELIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-23 | — | — | EP | disclosed |
| EP-1567498-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004048335-A2 | MANDELIC ACID DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-10 | — | — | WO | disclosed |