Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | FLT4 | P35916 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | AURKA | O14965 | 8/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | KIT | P10721 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | MST1R | Q04912 | 2/20 | 0.47 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2049622 | 0.91 | PDGFRB (0.49) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL2052872 | 0.89 | PDGFRB (0.52) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL2049861 | 0.86 | AURKA (0.67) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL2053145 | 0.85 | FLT3 (0.69) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL5042725 | 0.85 | PDGFRB (0.48) | PDGFRBFLT3FLT4KDRAURKA | |
| Hydrochloric Acid SCHEMBL5043171 | 0.84 | KDR (0.52) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL6026358 | 0.84 | PDGFRB (0.53) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL2052923 | 0.81 | PDGFRB (0.65) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL2049238 | 0.78 | AURKA (0.64) | PDGFRBFLT3FLT4KDRAURKA | |
| SCHEMBL3428755 | 0.78 | FLT4 (0.58) | PDGFRBFLT3FLT4AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | claimed |