Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1175909 | 1.00 | GSK3B (0.45) | GSK3BPDPK1JAK2AXLCCNC | |
| SCHEMBL5042826 | 0.89 | DYRK1A (0.39) | GSK3BJAK2DYRK1AMAPTMAPK1 | |
| SCHEMBL2600886 | 0.89 | AXL (0.41) | GSK3BAXLDYRK1AMAPTMAPK1 | |
| SCHEMBL2006524 | 0.89 | DYRK1A (0.39) | GSK3BJAK2DYRK1AMAPTMAPK1 | |
| SCHEMBL1175931 | 0.86 | GSK3B (0.52) | GSK3BDYRK1A | |
| SCHEMBL1175579 | 0.86 | DYRK1A (0.38) | GSK3BDYRK1AMAPTMAPK1WNT1 | |
| SCHEMBL5044513 | 0.86 | GSK3B (0.52) | GSK3BDYRK1A | |
| SCHEMBL5044466 | 0.86 | DYRK1A (0.38) | GSK3BDYRK1AMAPTMAPK1WNT1 | |
| SCHEMBL5042792 | 0.85 | DYRK1A (0.56) | GSK3BJAK2AXLDYRK1AWNT1 | |
| Hydrochloric Acid SCHEMBL1175804 | 0.85 | GSK3B (0.52) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |