Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14731813 | 0.84 | TMEM97 (0.86) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL5042778 | 0.80 | TMEM97 (0.63) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731886 | 0.79 | TMEM97 (0.77) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731807 | 0.79 | TMEM97 (0.77) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL19361170 | 0.79 | TMEM97 (0.67) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731804 | 0.78 | TMEM97 (1.00) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731805 | 0.78 | TMEM97 (1.00) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731907 | 0.76 | MEN1 (0.76) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL5042774 | 0.75 | TMEM97 (0.57) | TMEM97KCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731808 | 0.75 | TMEM97 (0.71) | TMEM97KCNH2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654260-A4 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PROD INC (US) | 2008-09-24 | — | — | EP | claimed |
| EP-1654260-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005011601-A2 | 6-MENBERED HETEROARYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS, INC. (US) | 2005-02-10 | — | — | WO | claimed |