Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 6/20 | 0.55 |
| ▸ | CA12 | O43570 | 9/20 | 0.39 |
| ▸ | CA1 | P00915 | 9/20 | 0.39 |
| ▸ | CA2 | P00918 | 9/20 | 0.39 |
| ▸ | CA4 | P22748 | 9/20 | 0.39 |
| ▸ | CA9 | Q16790 | 9/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6058696 | 0.90 | PTGER2 (0.66) | PTGER2CA12CA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL5046674 | 0.89 | PTGER2 (0.65) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5046401 | 0.88 | PTGER2 (0.58) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5050278 | 0.87 | PTGER2 (0.60) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5043201 | 0.86 | PTGER2 (0.60) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5048002 | 0.86 | PTGER2 (0.69) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5048025 | 0.85 | PTGER2 (0.41) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5043416 | 0.84 | PTGER2 (0.60) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5042979 | 0.82 | PTGER2 (0.63) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5047967 | 0.82 | PTGER2 (0.63) | PTGER2CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |