Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176315 | 1.00 | GSK3B (0.43) | GSK3BFLT3RBP4CDK2HSD11B1 | |
| Hydrochloric Acid SCHEMBL1176734 | 0.99 | GSK3B (0.43) | GSK3BFLT3RBP4CDK2HSD11B1 | |
| Formic Acid SCHEMBL5562459 | 0.96 | GSK3B (0.41) | GSK3BFLT3RBP4CDK2HSD11B1 | |
| SCHEMBL1176725 | 0.92 | GSK3B (0.46) | GSK3BFLT3RBP4CDK2CDK16 | |
| SCHEMBL1175931 | 0.92 | GSK3B (0.52) | GSK3BRBP4CDK2PRKAG1PRKAA1 | |
| SCHEMBL5044513 | 0.92 | GSK3B (0.52) | GSK3BRBP4CDK2PRKAG1PRKAA1 | |
| Hydrochloric Acid SCHEMBL1175804 | 0.91 | GSK3B (0.52) | GSK3BRBP4CDK2PRKAG1PRKAA1 | |
| SCHEMBL5039120 | 0.89 | DYRK1A (0.41) | GSK3BRBP4DYRK1A | |
| SCHEMBL1176208 | 0.89 | DYRK1A (0.41) | GSK3BRBP4DYRK1A | |
| Formic Acid SCHEMBL5556319 | 0.88 | GSK3B (0.49) | GSK3BRBP4CDK2PRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |