Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5043872 | 1.00 | CNR2 (0.49) | CNR2CNR1RORCPRSS12ALDH1A1 | |
| SCHEMBL5038488 | 0.87 | CNR1 (0.57) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL5038491 | 0.87 | CNR1 (0.57) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL5038531 | 0.87 | CNR1 (0.57) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL5043652 | 0.82 | CNR1 (0.50) | CNR2CNR1RAB9A | |
| SCHEMBL5037353 | 0.81 | CNR1 (0.49) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL5037352 | 0.81 | CNR1 (0.49) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL24976080 | 0.77 | CNR2 (0.48) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL24977371 | 0.73 | HDAC1 (0.51) | CNR2CNR1ALDH1A1RAB9ATDP1 | |
| SCHEMBL5037401 | 0.72 | CNR1 (0.61) | CNR2CNR1RORCALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342032-B2 | Thiazole derivatives having CB1-antagonistic, agonistic or partial agonistic activity | SOLVAY PHARMACEUTICALS, INC. (NL) | 2008-03-11 | — | — | US | disclosed |
| EP-1492779-A1 | THIAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC, AGONISTIC OR PARTIAL AGONISTIC ACTIVITY | Solvay Pharmaceuticals B.V. (NL) | 2005-01-05 | — | — | EP | disclosed |
| US-20040266841-A1 | Thiazole derivatives having cb1-antagonistic, agonistic or partial agonistic activity | ABBVIE B.V. (NL) | 2004-12-30 | — | — | US | disclosed |
| WO-2003078413-A1 | THIAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC, AGONISTIC OR PARTIAL AGONISTIC ACTIVITY | SOLVAY PHARMACEUTICALS B.V. (NL) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266841-A1 | Thiazole derivatives having cb1-antagonistic, agonistic or partial agonistic activity | CNR1, CNR2, CCKAR | CNR2 2/4885CNR1 1/4885RORC 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.