Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.53 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | GALR3 | O60755 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856443 | 1.00 | PLK1 (0.60) | PLK1TRPV1KDM4EPLK3S1PR2 | |
| SCHEMBL5043914 | 0.87 | PLK1 (0.59) | PLK1TRPV1KDM4EPLK3RORC | |
| SCHEMBL5039945 | 0.87 | PLK1 (0.59) | PLK1TRPV1KDM4EPLK3RORC | |
| SCHEMBL1854267 | 0.86 | PLK1 (0.58) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL1854194 | 0.86 | PLK1 (0.58) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL1858703 | 0.85 | PLK1 (0.57) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL1858706 | 0.85 | PLK1 (0.57) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL1855980 | 0.85 | PLK1 (0.57) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL1855979 | 0.85 | PLK1 (0.57) | PLK1TRPV1KDM4EPLK3NR1H4 | |
| SCHEMBL4966334 | 0.85 | S1PR1 (0.57) | PLK1KDM4ES1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732534-B1 | USE OF METHYLENE AMIDE DERIVATIVES IN CARDIOVASCULAR DISORDERS | SERONO LAB (CH) | 2008-07-23 | — | — | EP | claimed |