Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 19/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046083 | 0.99 | CNR2 (0.73) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3415849 | 0.97 | CNR2 (0.73) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL29510061 | 0.85 | CNR2 (1.00) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3380524 | 0.85 | CNR2 (1.00) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3382521 | 0.84 | CNR2 (1.00) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3378679 | 0.82 | CNR2 (0.71) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3382367 | 0.82 | CNR2 (1.00) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL4893858 | 0.82 | CNR2 (0.67) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3382659 | 0.81 | CNR2 (0.75) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 | |
| SCHEMBL3381334 | 0.81 | CNR2 (0.72) | CNR2CYP2C9CYP2C19CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878725-A2 | Pyrimidine derivatives and their use as CB2 modulators | GLAXO GROUP LIMITED (GB) | 2008-01-16 | — | — | EP | disclosed |
| EP-1539712-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS CB2 MODULATORS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018433-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS CB2 MODULATORS | GLAXO GROUP LIMITED (GB) | 2004-03-04 | — | — | WO | disclosed |