Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 8/20 | 0.42 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039865 | 0.92 | SREBF2 (0.43) | HTR2AHTR2CSLC6A4SREBF2SREBF1 | |
| SCHEMBL5047645 | 0.90 | SREBF2 (0.42) | HTR2AHTR2CSLC6A4SREBF2SREBF1 | |
| SCHEMBL5043561 | 0.89 | HTR2A (0.45) | HTR2AHTR2CSLC6A4KLKB1IDH1 | |
| SCHEMBL5133254 | 0.89 | CDC25A (0.42) | SREBF2SREBF1PDE10AKLKB1IDH1 | |
| SCHEMBL5043728 | 0.89 | SREBF2 (0.41) | HTR2AHTR2CSLC6A4SREBF2SREBF1 | |
| SCHEMBL5046013 | 0.88 | HTR2A (0.45) | HTR2AHTR2CSLC6A4KLKB1IDH1 | |
| SCHEMBL5048671 | 0.88 | SREBF2 (0.42) | SREBF2SREBF1PDE10AKLKB1ALDH1A1 | |
| SCHEMBL5048633 | 0.88 | HTR2A (0.49) | HTR2AHTR2CSLC6A4KLKB1IDH1 | |
| SCHEMBL5045693 | 0.88 | HTR2A (0.45) | HTR2AHTR2CSLC6A4KLKB1IDH1 | |
| SCHEMBL5048584 | 0.87 | SREBF2 (0.47) | SREBF2SREBF1IDH1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583762-B1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-7135488-B2 | Pyrrolyl-thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-11-14 | — | — | US | disclosed |
| EP-1583762-A1 | PYRROLYL-THIAZOLES AND THEIR USE AS CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004060888-A1 | NOVEL CB 1 RECEPTOR INVERSE AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-22 | — | — | WO | disclosed |