Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 10/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | PGD | P52209 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1270333 | 0.81 | LPAR3 (0.46) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| Phosphoric Acid SCHEMBL27874485 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL26985916 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL2048486 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| Methane SCHEMBL7755990 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL31506206 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL28933243 | 0.79 | LPAR3 (0.45) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL5909088 | 0.77 | LPAR3 (0.43) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL5963725 | 0.76 | LPAR3 (0.42) | LPAR3LPAR2LPAR1PGK1PGK2 | |
| SCHEMBL5586194 | 0.76 | LPAR3 (0.47) | LPAR3LPAR2LPAR1PGK1PGK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1613619-A1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | AstraZeneca AB (SE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-11-04 | — | — | WO | disclosed |