Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.40 |
| ▸ | GSK3B | P49841 | 12/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1176539 | 1.00 | DYRK1A (0.40) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| Formic Acid SCHEMBL5562045 | 0.96 | DYRK1A (0.38) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| SCHEMBL1176680 | 0.93 | CHEK1 (0.41) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| SCHEMBL5044696 | 0.93 | CHEK1 (0.41) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| Formic Acid SCHEMBL5562022 | 0.89 | CHEK1 (0.38) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| SCHEMBL5038892 | 0.87 | DYRK1A (0.41) | DYRK1AGSK3BCLK2CLK3WNT1 | |
| SCHEMBL1175540 | 0.87 | DYRK1A (0.41) | DYRK1AGSK3BCLK2CLK3WNT1 | |
| SCHEMBL1175940 | 0.86 | GSK3B (0.42) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| SCHEMBL1176793 | 0.86 | GSK3B (0.42) | DYRK1AGSK3BCLK2CLK3CHEK1 | |
| SCHEMBL1175808 | 0.84 | HAO1 (0.44) | DYRK1AGSK3BCLK2CLK3WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396833-B2 | Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-07-08 | — | — | US | claimed |
| EP-1697378-B1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARM CORP (US) | 2007-11-21 | — | — | EP | claimed |