Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 11/20 | 0.52 |
| ▸ | CA1 | P00915 | 11/20 | 0.52 |
| ▸ | CA2 | P00918 | 11/20 | 0.52 |
| ▸ | CA4 | P22748 | 11/20 | 0.52 |
| ▸ | CA9 | Q16790 | 11/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046418 | 0.93 | PTGER2 (0.62) | PTGER2CA12CA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL5046940 | 0.88 | CA12 (0.65) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5048002 | 0.86 | PTGER2 (0.69) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5046622 | 0.85 | PTGER2 (0.59) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5046365 | 0.83 | CA12 (0.57) | PTGER2CA12CA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL5048182 | 0.82 | PTGER2 (0.75) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5043167 | 0.82 | PTGER2 (0.64) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5049396 | 0.82 | CA12 (0.55) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5043104 | 0.81 | PTGER2 (0.59) | PTGER2CA12CA1CA2CA4 | |
| SCHEMBL5140001 | 0.80 | PTGER2 (0.81) | PTGER2CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442702-B2 | Treatment of bone disorders; carboxy derivatives | PFIZER INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1021410-B1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER (US) | 2006-12-27 | — | — | EP | disclosed |
| US-6498172-B1 | (3-(((4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO)-METHYL) -PHENOXY)-ACETIC ACID OR SALT; TREATING SUCH AS OSTEOPOROSIS | PFIZER INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1021410-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999019300-A1 | PROSTAGLANDIN AGONISTS AND THEIR USE TO TREAT BONE DISORDERS | PFIZER INC. (US) | 1999-04-22 | — | — | WO | disclosed |