Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 1.00 |
| ▸ | RAD52 | P43351 | 4/20 | 0.85 |
| ▸ | POLB | P06746 | 4/20 | 0.85 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.85 |
| ▸ | ACP1 | P24666 | 3/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | PDE5A | O76074 | 3/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713606 | 1.00 | TLR9 (1.00) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL1085391 | 0.97 | TLR9 (0.95) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL29713600 | 0.97 | TLR9 (0.95) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL14758542 | 0.92 | RAD52 (1.00) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL16220560 | 0.91 | TLR9 (0.83) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL14758284 | 0.91 | POLB (0.86) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL3460899 | 0.90 | TLR9 (0.81) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL1085522 | 0.84 | POLB (0.83) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL23748991 | 0.84 | TLR9 (0.72) | TLR9RAD52POLBSMARCA2ACP1 | |
| SCHEMBL30125496 | 0.84 | TLR9 (0.72) | TLR9RAD52POLBSMARCA2ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170354655-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC | 2017-12-14 | — | — | US | claimed |
| EP-3220912-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | Pharmacyclics LLC (US) | 2017-09-27 | — | — | EP | claimed |
| WO-2016081460-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC (US) | 2016-05-26 | — | — | WO | claimed |
| EP-4013880-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | CureVac AG (DE) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021028439-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | CUREVAC AG (DE) | 2021-02-18 | — | — | WO | disclosed |
| US-20170354655-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC | 2017-12-14 | — | — | US | disclosed |
| EP-3220912-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | Pharmacyclics LLC (US) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016081460-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC (US) | 2016-05-26 | — | — | WO | disclosed |
| US-7410975-B2 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7410975-B2 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-7410975-B2 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2008-08-12 | — | — | US | disclosed |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20050119273-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119273-A1 | Small molecule toll-like receptor (TLR) antagonists | TLR3, TLR8, TLR7 | TLR9 5/4885RAD52 671/4885POLB 3043/4885 |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | TLR3, TLR8, TLR7 | TLR9 5/4885RAD52 671/4885POLB 3043/4885 |
| US-20170354655-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | BTK, TLR3, TLR9 | TLR9 3/4885RAD52 2152/4885POLB 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.