Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 14/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6464533 | 0.94 | HSD17B3 (0.56) | HSD17B3POLBPARP14IDH1KDM4E | |
| SCHEMBL6464540 | 0.94 | HSD17B3 (0.56) | HSD17B3POLBPARP14IDH1KDM4E | |
| SCHEMBL5038704 | 0.83 | HSD17B3 (0.56) | HSD17B3 | |
| SCHEMBL5038709 | 0.83 | HSD17B3 (0.56) | HSD17B3 | |
| SCHEMBL5048200 | 0.80 | HSD17B3 (0.59) | HSD17B3 | |
| SCHEMBL5048187 | 0.80 | HSD17B3 (0.59) | HSD17B3 | |
| SCHEMBL5042553 | 0.80 | HSD17B3 (0.64) | HSD17B3 | |
| SCHEMBL5042551 | 0.80 | HSD17B3 (0.64) | HSD17B3 | |
| SCHEMBL5044242 | 0.79 | HSD17B3 (0.58) | HSD17B3 | |
| SCHEMBL5044233 | 0.79 | HSD17B3 (0.58) | HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378426-B2 | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-27 | — | — | US | disclosed |