Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 12/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042659 | 0.92 | NR1H2 (0.36) | EEDNR1H2ATRATRIPBRD4 | |
| SCHEMBL3033517 | 0.92 | EED (0.34) | EEDNR1H2TGFBR1ATRATRIP | |
| SCHEMBL3046959 | 0.88 | NR1H2 (0.41) | NR1H2BRD4CREBBPNR1H3 | |
| SCHEMBL3049701 | 0.88 | NR1H2 (0.37) | NR1H2ATRATRIPBRD4CREBBP | |
| SCHEMBL3039052 | 0.87 | NR1H2 (0.37) | NR1H2ATRATRIPBRD4CREBBP | |
| SCHEMBL3044637 | 0.87 | NR1H2 (0.39) | NR1H2NR1H3TBK1 | |
| SCHEMBL3039181 | 0.86 | NR1H2 (0.36) | NR1H2BRD4CREBBPNR1H3TBK1 | |
| SCHEMBL3048520 | 0.86 | NR1H2 (0.38) | NR1H2ATRATRIPBRD4CREBBP | |
| SCHEMBL3047413 | 0.86 | NR1H2 (0.36) | NR1H2ATRATRIPBRD4CREBBP | |
| SCHEMBL3048979 | 0.86 | NR1H2 (0.36) | NR1H2ATRATRIPBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |