Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132487 | 0.90 | AURKA (0.67) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5048606 | 0.89 | AURKA (0.64) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5132484 | 0.89 | AURKA (0.67) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL3432058 | 0.89 | AURKA (0.79) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL2053172 | 0.85 | AURKA (0.69) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL3424557 | 0.85 | AURKA (0.66) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL3490956 | 0.84 | AURKA (0.80) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL3489920 | 0.84 | AURKA (0.80) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL3429579 | 0.83 | AURKA (0.58) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL2053420 | 0.83 | AURKA (0.64) | AURKAPDGFRBFLT4FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635837-B1 | (3-((QUINAZOLIN-4-YL)AMINO)-1H-PYRAZOL-1-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ASTRAZENECA AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| EP-1635837-A1 | (3-((QUINAZOLIN-4-YL)AMINO)-1H-PYRAZOL-1-YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004105764-A1 | (3- ((QUINAZOLIN-4-YL) AMINO )-1H-PYRAZOL-1-YL) ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS AURORA KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ASTRAZENECA AB (SE) | 2004-12-09 | — | — | WO | disclosed |