Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708746 | 0.87 | KCNH2 (0.41) | KCNH2USP2HTTCHRM1CHRM5 | |
| SCHEMBL708745 | 0.87 | KCNH2 (0.41) | KCNH2USP2HTTCHRM1CHRM5 | |
| SCHEMBL706228 | 0.74 | KCNH2 (0.55) | KCNH2CHRM1CHRM5CHRM3 | |
| SCHEMBL706227 | 0.74 | KCNH2 (0.55) | KCNH2CHRM1CHRM5CHRM3 | |
| SCHEMBL921491 | 0.72 | KCNH2 (0.61) | KCNH2CHRM1CHRM5CHRM3CYP3A4 | |
| SCHEMBL705187 | 0.71 | KCNH2 (0.53) | KCNH2HTTCHRM1CHRM5CHRM3 | |
| SCHEMBL708349 | 0.69 | KCNH2 (0.59) | KCNH2CHRM1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL706005 | 0.69 | KCNH2 (0.56) | KCNH2CHRM1CHRM5CHRM3DRD2 | |
| Trifluoroacetic Acid SCHEMBL708560 | 0.68 | KCNH2 (0.53) | KCNH2CHRM1CHRM5CHRM3CYP3A4 | |
| SCHEMBL707478 | 0.68 | CHRM1 (0.39) | KCNH2CHRM1CHRM5CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | claimed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | claimed |