Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | IL2 | P60568 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517951 | 0.90 | KMT2A (0.59) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5530010 | 0.89 | MEN1 (0.52) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5048908 | 0.83 | KMT2A (0.54) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5049839 | 0.83 | IL2 (0.59) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5049909 | 0.82 | IL2 (0.58) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5051473 | 0.82 | KMT2A (0.53) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5046929 | 0.81 | IL2 (0.53) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5049029 | 0.80 | KMT2A (0.51) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5052697 | 0.80 | KMT2A (0.51) | KMT2AMEN1ALDH1A1IL2GAA | |
| SCHEMBL5048892 | 0.80 | KMT2A (0.51) | KMT2AMEN1ALDH1A1IL2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983980-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087427-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | disclosed |