Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 8/20 | 0.37 |
| ▸ | CCND1 | P24385 | 7/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054862 | 0.92 | MAPK14 (0.42) | MAPK14MAPK12MAPK11MAPK13CDK4 | |
| SCHEMBL5052268 | 0.91 | NTRK1 (0.38) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL5056323 | 0.89 | MAP3K7 (0.46) | MAPK14MAPK12MAPK11MAPK13CDK4 | |
| SCHEMBL5062229 | 0.89 | NTRK1 (0.44) | MAPK14MAPK12MAPK11MAPK13CDK4 | |
| SCHEMBL5052221 | 0.89 | MAPK14 (0.52) | MAPK14MAPK12MAPK11MAPK13MAP3K7 | |
| SCHEMBL5062642 | 0.89 | MAPK14 (0.36) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL5052203 | 0.88 | NTRK1 (0.46) | MAPK14MAPK12MAPK11MAPK13CDK4 | |
| SCHEMBL5056531 | 0.87 | NTRK1 (0.36) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL5062070 | 0.86 | NTRK1 (0.46) | MAPK14MAPK12MAPK11MAPK13 | |
| SCHEMBL5060663 | 0.82 | MAP3K7 (0.40) | MAPK14MAPK12MAPK11MAPK13CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | MAPK14 100/4885MAPK12 99/4885MAPK11 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.