Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 5/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 5/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 5/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | KRAS | P01116 | 3/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054894 | 0.93 | BRAF (0.42) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5055154 | 0.93 | KCNJ6 (0.39) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5052297 | 0.92 | KCNJ6 (0.46) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5060424 | 0.92 | MAPK14 (0.44) | BRAFRAF1KRASKDRMAP2K2 | |
| SCHEMBL5062365 | 0.91 | KCNJ6 (0.49) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5062241 | 0.90 | BRAF (0.46) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5054882 | 0.89 | BRAF (0.38) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5056347 | 0.89 | BRAF (0.39) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5055028 | 0.89 | BRAF (0.39) | KCNJ6KCNJ5KCNJ3BRAFRAF1 | |
| SCHEMBL5054588 | 0.89 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | KCNJ6 3243/4885KCNJ5 3284/4885KCNJ3 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.