Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 8/20 | 0.43 |
| ▸ | RAF1 | P04049 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | KRAS | P01116 | 3/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.37 |
| ▸ | LTK | P29376 | 2/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062135 | 0.91 | MAPK14 (0.52) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5062514 | 0.91 | BRAF (0.47) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5062653 | 0.91 | MAPK14 (0.50) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5052414 | 0.90 | MAPK14 (0.51) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5052979 | 0.89 | MAPK14 (0.46) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5055287 | 0.89 | MAPK14 (0.44) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5054509 | 0.89 | BRAF (0.44) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5060216 | 0.88 | MAPK14 (0.47) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL4425718 | 0.88 | BRAF (0.48) | MAPK14MAPK12MAPK11MAPK13BRAF | |
| SCHEMBL5056461 | 0.88 | MAPK14 (0.42) | MAPK14MAPK12MAPK11MAPK13BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | MAPK14 100/4885MAPK12 99/4885MAPK11 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.