Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062240 | 0.93 | NTRK1 (0.38) | MAP3K7TAB1NTRK1MAPK14MAPK12 | |
| SCHEMBL5061990 | 0.91 | MAP3K7 (0.46) | MAP3K7TAB1NTRK1DYRK3RPS6KB1 | |
| SCHEMBL5054654 | 0.91 | MAPK14 (0.46) | NTRK1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5054902 | 0.91 | NTRK1 (0.47) | NTRK1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5056531 | 0.89 | NTRK1 (0.36) | NTRK1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5052329 | 0.89 | NTRK1 (0.48) | NTRK1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5056323 | 0.88 | MAP3K7 (0.46) | MAP3K7TAB1NTRK1DYRK3RPS6KB1 | |
| SCHEMBL5054922 | 0.82 | MAP3K7 (0.47) | MAP3K7TAB1DYRK3RPS6KB1MARK3 | |
| SCHEMBL5056355 | 0.81 | MAPK14 (0.50) | NTRK1MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL5055029 | 0.81 | NTRK1 (0.51) | NTRK1MAPK14MAPK12MAPK13MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | MAP3K7 22/4885TAB1 240/4885NTRK1 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.