Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.67 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.57 |
| ▸ | APP | P05067 | 4/20 | 0.56 |
| ▸ | CTSD | P07339 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5050372 | 0.95 | BACE1 (0.60) | BACE1BACE2APPCTSDLMNA | |
| SCHEMBL5050545 | 0.91 | BACE1 (0.55) | BACE1BACE2APPCTSDLMNA | |
| SCHEMBL5050369 | 0.90 | BACE1 (0.55) | BACE1BACE2APPCTSDLMNA | |
| SCHEMBL14136382 | 0.90 | BACE1 (0.82) | BACE1BACE2APPCTSD | |
| SCHEMBL5053690 | 0.87 | BACE1 (0.59) | BACE1BACE2APPCTSDLMNA | |
| SCHEMBL8269001 | 0.87 | BACE1 (0.59) | BACE1BACE2APPCTSDLMNA | |
| SCHEMBL5051636 | 0.83 | BACE1 (0.56) | BACE1BACE2APPCTSD | |
| SCHEMBL5198863 | 0.83 | BACE1 (0.78) | BACE1BACE2APP | |
| SCHEMBL5050467 | 0.82 | BACE1 (0.56) | BACE1BACE2CTSD | |
| SCHEMBL5049121 | 0.82 | BACE1 (0.54) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | COMENTIS, INC. (US) | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | BACE1, BACE2, PSEN1 | BACE1 1/4885BACE2 2/4885APP 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.