Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.52 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.51 |
| ▸ | CTSD | P07339 | 5/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5055419 | 0.87 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL5053628 | 0.82 | BACE1 (0.74) | BACE1BACE2CTSD | |
| SCHEMBL5055423 | 0.81 | BACE1 (0.74) | BACE1BACE2CTSD | |
| SCHEMBL5049157 | 0.80 | BACE1 (0.75) | BACE1BACE2CTSD | |
| SCHEMBL5055391 | 0.77 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL5055412 | 0.77 | BACE1 (0.65) | BACE1BACE2CTSD | |
| SCHEMBL5051650 | 0.74 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL5050491 | 0.73 | BACE1 (0.61) | BACE1BACE2CTSD | |
| SCHEMBL5049137 | 0.73 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL8270178 | 0.73 | CCR1 (0.47) | BACE1BACE2CTSDPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | COMENTIS, INC. (US) | 2008-08-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207527-A1 | Bicyclic Compounds Which Inhibit Beta-Secretase Activity and Methods of Use Thereof | BACE1, BACE2, PSEN1 | BACE1 1/4885BACE2 2/4885CTSD 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.