⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505755 | 1.00 | — | — | |
| SCHEMBL1524402 | 0.83 | HPGD (0.31) | — | |
| SCHEMBL1524477 | 0.83 | HPGD (0.31) | — | |
| SCHEMBL1524401 | 0.83 | HPGD (0.31) | — | |
| SCHEMBL9311468 | 0.73 | HPGD (0.32) | — | |
| SCHEMBL9311464 | 0.73 | HPGD (0.32) | — | |
| SCHEMBL9655973 | 0.71 | — | — | |
| SCHEMBL8969314 | 0.71 | — | — | |
| SCHEMBL5855845 | 0.71 | — | — | |
| SCHEMBL5855847 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2012-02-02 | — | — | US | claimed |
| US-20120029226-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2012-02-02 | — | — | US | disclosed |
| EP-2393771-A1 | Method for the synthesis of chiral alpha-aryl propionic acid derivatives | DSM IP Assets B.V. (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089343-A1 | METHOD FOR THE SYNTHESIS OF CHIRAL ALPHA-ARYL PROPIONIC ACID DERIVATIVES | DSM IP ASSETS B.V. (NL) | 2010-08-12 | — | — | WO | disclosed |
| EP-0862554-B1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | HOFFMANN LA ROCHE (CH) | 2004-10-20 | — | — | EP | disclosed |
| US-5958956-A | SKIN DISORDERS; WOUND HEALING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0862554-A1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-09 | — | — | EP | disclosed |
| US-5726191-A | TREATEMENT OF LIGHT AND AGE DAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1997018192-A1 | AROMATIC CARBOXYLIC ACID ESTERS, THE PRODUCTION OF SAME AND USE OF SAME AS MEDICAMENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-05-22 | — | — | WO | disclosed |
| US-5536732-A | REDUCING INFECTIOUSNESS OF HIV | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0454580-B1 | Novel nojirimycin derivatives | MERRELL DOW PHARMA (US) | 1995-12-27 | — | — | EP | disclosed |
| US-5252587-A | Viricides, aids therapy, antidiabetic agent | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0454580-A2 | Novel nojirimycin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-30 | — | — | EP | disclosed |
| EP-0453692-A1 | Novel nojirimycin derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-10-30 | — | — | EP | disclosed |