Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062924 | 1.00 | TDP1 (0.46) | TDP1L3MBTL1ATMPPARGBCHE | |
| SCHEMBL1261877 | 0.85 | MEN1 (0.51) | TDP1L3MBTL1ATMPPARGBCHE | |
| SCHEMBL1826831 | 0.83 | TDP1 (0.47) | TDP1L3MBTL1ATMPPARGBCHE | |
| SCHEMBL28842455 | 0.81 | TSHR (0.46) | TDP1HPGDKMT2AIRAK4KDM4E | |
| SCHEMBL7976424 | 0.81 | KMT2A (0.51) | L3MBTL1ATMBCHEKMT2AIRAK4 | |
| SCHEMBL1983875 | 0.81 | TSHR (0.46) | TDP1HPGDKMT2AIRAK4KDM4E | |
| SCHEMBL3199566 | 0.81 | KMT2A (0.51) | L3MBTL1ATMBCHEKMT2AIRAK4 | |
| SCHEMBL8399530 | 0.81 | CA1 (0.45) | TDP1L3MBTL1ATMHPGDMEN1 | |
| SCHEMBL17502798 | 0.81 | TDP1 (0.49) | TDP1L3MBTL1ATMPPARGBCHE | |
| SCHEMBL30605965 | 0.81 | TDP1 (0.49) | TDP1L3MBTL1ATMPPARGBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080254033-A1 | Pharmaceutical Compositions Containing Antagonists to Lrp4, Lrp8 or Megalin for Treatment of Diseases | FIVE PRIME THERAPEUTICS, INC. | 2008-10-16 | — | — | US | disclosed |