Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.43 |
| ▸ | SYK | P43405 | 11/20 | 0.43 |
| ▸ | SRC | P12931 | 10/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 8/20 | 0.43 |
| ▸ | KRAS | P01116 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066988 | 0.92 | MAPK14 (0.44) | BRAFMAPK14SYKSRCMAPK13 | |
| SCHEMBL5060109 | 0.89 | MAPK14 (0.50) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL4425259 | 0.88 | MAPK14 (0.52) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL4427768 | 0.87 | BRAF (0.49) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL5055112 | 0.87 | MAPK14 (0.53) | RAF1BRAFMAPK14SRCMAPK13 | |
| SCHEMBL5055164 | 0.87 | BRAF (0.45) | RAF1BRAFMAPK14SYKSRC | |
| SCHEMBL5052173 | 0.87 | ABL1 (0.47) | RAF1BRAFMAPK14SYKSRC | |
| SCHEMBL5060539 | 0.87 | ABL1 (0.55) | RAF1BRAFMAPK14SYKSRC | |
| SCHEMBL5052284 | 0.86 | MAPK14 (0.47) | RAF1BRAFMAPK14SYKSRC | |
| SCHEMBL5062514 | 0.86 | BRAF (0.47) | RAF1BRAFMAPK14SRCMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | RAF1 55/4885BRAF 2/4885MAPK14 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.