Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.76 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.76 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.76 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.76 |
| ▸ | TP53 | P04637 | 6/20 | 0.76 |
| ▸ | HTR1A | P08908 | 5/20 | 0.76 |
| ▸ | TSHR | P16473 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.76 |
| ▸ | DRD1 | P21728 | 4/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.76 |
| ▸ | THPO | P40225 | 4/20 | 0.76 |
| ▸ | MTOR | P42345 | 4/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promazine SCHEMBL5059998 | 1.00 | CYP2D6 (0.76) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Chlorpromazine SCHEMBL8701719 | 0.90 | CYP1A2 (0.81) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Chlorpromazine SCHEMBL8701718 | 0.90 | CYP1A2 (0.81) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL204733 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL30616039 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL204734 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL30620438 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL7253707 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL21803694 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 | |
| Acepromazine SCHEMBL29876174 | 0.89 | CYP2D6 (0.88) | CYP2D6CYP1A2TP53HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1913132-A1 | CLONED CANINES AND METHOD FOR PRODUCING THEREOF | Seoul National University Industry Foundation (KR) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007013763-A1 | CLONED CANINES AND METHOD FOR PRODUCING THEREOF | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-02-01 | — | — | WO | disclosed |