Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 10/20 | 0.50 |
| ▸ | RPS6KA1 | Q15418 | 6/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 5/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.45 |
| ▸ | AKT2 | P31751 | 4/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065504 | 0.96 | AKT1 (0.54) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4066999 | 0.89 | RPS6KA5 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Hydrochloric Acid SCHEMBL5062970 | 0.89 | RPS6KA5 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5062934 | 0.87 | AKT1 (0.52) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5062862 | 0.86 | AKT1 (0.67) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5067633 | 0.85 | SLC2A1 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Trifluoroacetic Acid SCHEMBL4389888 | 0.84 | AKT1 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4066084 | 0.83 | RPS6KA5 (0.57) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5066182 | 0.82 | AKT1 (0.53) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 | |
| SCHEMBL4067021 | 0.82 | AKT1 (0.50) | SLC2A1AKT1RPS6KA1RPS6KA5ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SLC2A1 3039/4885AKT1 5/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.