Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 7/20 | 0.43 |
| ▸ | CDK8 | P49336 | 7/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.43 |
| ▸ | PAK4 | O96013 | 3/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.41 |
| ▸ | PRKX | P51817 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | GRK5 | P34947 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5065442 | 0.89 | MAPK14 (0.57) | MAPK14RAF1BRAFEPHB2RET | |
| SCHEMBL4419974 | 0.87 | BRAF (0.46) | MAPK14RAF1BRAFMAPK13MAPK12 | |
| SCHEMBL5055112 | 0.82 | MAPK14 (0.53) | MAPK14RAF1BRAFMAPK9MAPK13 | |
| SCHEMBL4425259 | 0.81 | MAPK14 (0.52) | MAPK14RAF1BRAFMAPK13MAPK12 | |
| SCHEMBL4272187 | 0.80 | BRAF (0.44) | MAPK14RAF1BRAFPDGFRAABL1 | |
| SCHEMBL4563409 | 0.80 | MAPK14 (0.53) | MAPK14BRAFRETCDK8PDGFRA | |
| SCHEMBL5061867 | 0.80 | BRAF (0.58) | MAPK14RAF1BRAFEPHB2RET | |
| SCHEMBL5055067 | 0.80 | BRAF (0.45) | MAPK14RAF1BRAFCDK8MAPK9 | |
| SCHEMBL5065364 | 0.79 | MAPK14 (0.53) | MAPK14BRAFMAPK9MAPK13MAPK12 | |
| SCHEMBL5057688 | 0.79 | FGFR1 (0.45) | MAPK14RAF1BRAFPDGFRAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | claimed |
| US-8188113-B2 | For example, 1-(5-(2-amino-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)-2-fluorophenyl)-3-(3-tert-butyl-1-phenyl-1H-pyrazol-5-yl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114006-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | BRAF, PRKDC, RAF1 | MAPK14 240/4885RAF1 3/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.