Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.81 |
| ▸ | NEK2 | P51955 | 2/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | STK3 | Q13188 | 1/20 | 0.51 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5062900 | 0.91 | PLK1 (0.83) | PLK1NEK2IKBKE | |
| SCHEMBL5062768 | 0.90 | PLK1 (0.80) | PLK1NEK2IKBKEMAP4K4CSF1R | |
| SCHEMBL5062124 | 0.90 | PLK1 (0.80) | PLK1NEK2IKBKE | |
| SCHEMBL5062371 | 0.90 | PLK1 (1.00) | PLK1NEK2MAP4K4CSF1RPIM1 | |
| SCHEMBL5065742 | 0.86 | PLK1 (0.79) | PLK1NEK2IKBKEMAP4K4CSF1R | |
| SCHEMBL5066012 | 0.85 | PLK1 (0.80) | PLK1NEK2MAP4K4CSF1RPIM1 | |
| SCHEMBL3251745 | 0.81 | PLK1 (0.65) | PLK1IKBKE | |
| Gw804482X SCHEMBL5058212 | 0.81 | PLK1 (1.00) | PLK1NEK2MAP4K4CSF1RPIM1 | |
| SCHEMBL5063267 | 0.81 | PLK1 (0.84) | PLK1NEK2IKBKEMAP4K4CSF1R | |
| SCHEMBL5063329 | 0.81 | PLK1 (0.60) | PLK1NEK2IKBKEMAP4K4CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269298-A1 | Benzimidazol-1-YL-thiophene compounds for the treatment of cancer | ANDREWS CLARENCE W | 2008-10-30 | — | — | US | disclosed |
| US-20060074119-A1 | Thiophene compounds | SMITHKLINE BEECHAM CORPORATION | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074119-A1 | Thiophene compounds | TPMT, ABCB1, CYP3A5 | PLK1 2123/4885NEK2 4031/4885IKBKE 3524/4885 |
| US-20080269298-A1 | Benzimidazol-1-YL-thiophene compounds for the treatment of cancer | ABCB1, TP53, CCNI | PLK1 130/4885NEK2 636/4885IKBKE 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.