Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 11/20 | 0.35 |
| ▸ | NPY1R | P25929 | 6/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 4/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.31 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.31 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27561248 | 0.88 | SLC7A5 (0.44) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL6568443 | 0.88 | SLC7A5 (0.44) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL6568441 | 0.88 | SLC7A5 (0.44) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL15201550 | 0.87 | NPY4R (0.37) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL13733046 | 0.87 | OTC (0.40) | NPY4RNPY1RNPY2RNPY5ROTC | |
| Cystine SCHEMBL8018228 | 0.87 | SLC7A5 (0.35) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Cystine SCHEMBL8018231 | 0.87 | SLC7A5 (0.35) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL9875878 | 0.86 | GSR (0.39) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL16679102 | 0.85 | SLC7A5 (0.41) | NPY4RNPY1RSLC7A5NPY2RNPY5R | |
| Arginine SCHEMBL16679101 | 0.85 | SLC7A5 (0.41) | NPY4RNPY1RSLC7A5NPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318960-A1 | PAR2-modulating compounds and their use | ACADIA PHARMACEUTICALS INC. | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318960-A1 | PAR2-modulating compounds and their use | F2RL1, F2R, F2RL3 | NPY4R 1101/4885NPY1R 570/4885SLC7A5 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.