Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.49 |
| ▸ | RPS6KA1 | Q15418 | 8/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.41 |
| ▸ | AKT2 | P31751 | 4/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5063595 | 0.88 | AKT1 (0.62) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL5058416 | 0.86 | AKT1 (0.49) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL5062485 | 0.86 | AKT1 (0.50) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL5066208 | 0.85 | AKT1 (0.54) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL3488757 | 0.83 | AKT1 (0.66) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL3489269 | 0.81 | AKT1 (0.65) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL5062976 | 0.79 | AKT1 (0.69) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL5063656 | 0.79 | AKT1 (0.44) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| SCHEMBL4067805 | 0.79 | AKT1 (0.75) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 | |
| Trifluoroacetic Acid SCHEMBL5062862 | 0.77 | AKT1 (0.67) | AKT1RPS6KA1RPS6KA5ROCK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | AKT1 5/4885RPS6KA1 127/4885RPS6KA5 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.