Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5549133 | 0.84 | POLB (0.49) | HRH3POLBSMN1; SMN2AKR1C3HRH4 | |
| SCHEMBL5039493 | 0.78 | F10 (0.47) | HRH3 | |
| SCHEMBL4566701 | 0.77 | HRH4 (0.48) | HRH3AKR1C3HRH4 | |
| SCHEMBL2347853 | 0.75 | POLB (0.63) | HRH3POLBSMN1; SMN2AKR1C3HRH4 | |
| Hydrochloric Acid SCHEMBL4566573 | 0.74 | HRH4 (0.61) | HRH3AKR1C3HRH4 | |
| SCHEMBL605846 | 0.72 | HRH4 (0.73) | HRH3POLBSMN1; SMN2AKR1C3HRH4 | |
| SCHEMBL1652273 | 0.70 | KDM5A (0.58) | HRH3 | |
| SCHEMBL1378962 | 0.70 | HRH3 (1.00) | HRH3 | |
| SCHEMBL1377980 | 0.70 | HRH3 (1.00) | HRH3 | |
| SCHEMBL3253717 | 0.68 | POLB (1.00) | HRH3POLBSMN1; SMN2AKR1C3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957479-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007062999-A2 | 1,5-SUBSTITUTED INDOL-2-YL AMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |