⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252367 | 0.90 | TSHR (0.30) | — | |
| SCHEMBL7262903 | 0.90 | TSHR (0.30) | — | |
| SCHEMBL7858703 | 0.90 | TSHR (0.30) | — | |
| Hydrochloric Acid SCHEMBL25380883 | 0.89 | — | — | |
| SCHEMBL5063697 | 0.83 | — | — | |
| SCHEMBL5067027 | 0.83 | — | — | |
| Glycerin SCHEMBL7951846 | 0.81 | — | — | |
| SCHEMBL26653603 | 0.81 | — | — | |
| SCHEMBL23384350 | 0.81 | TSHR (0.31) | — | |
| SCHEMBL9235878 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193384-B2 | Synthesized using diphosphitylating reagents via solid-phase synthesis; antisense therapy; genetic disorders; anticarcinogenic agents, viricides | Board of Governors for Higher Education, State of Rhode Island and Providence Plantation (US) | 2012-06-05 | — | — | US | disclosed |
| US-20080207551-A1 | MODIFIED OLIGONUCLEOTIDES CONTAINING DIPHOSPHODIESTER INTERNUCLEOTIDE LINKAGES | BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE (US) | 2008-08-28 | — | — | US | disclosed |
| EP-1910394-A2 | MODIFIED OLIGONUCLEOTIDES CONTAINING DIPHOSPHODIESTER INTERNUCLEOTIDE LINKAGES | The Board of Governors for Higher Education State of Rhode Island And Providence Plantations (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007030227-A2 | MODIFIED OLIGONUCLEOTIDES CONTAINING DIPHOSPHODIESTER INTERNUCLEOTIDE LINKAGES | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, (US) | 2007-03-15 | — | — | WO | disclosed |