SCHEMBL5065065

SCHEMBL5065065

CC1(C)COCCn2c1nc(C(=O)NCc1ccc(F)cc1-n1ccnn1)c(O)c2=O

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.35
KCNH2 Q12809 1/20 0.34
KCNK3 O14649 3/20 0.33
EGLN1 Q9GZT9 2/20 0.32
DDR1 Q08345 1/20 0.31
DDR2 Q16832 1/20 0.31
CNR1 P21554 2/20 0.31
HDAC3 O15379 1/20 0.31
HDAC2 Q92769 1/20 0.31
SLC22A2 O15244 1/20 0.31
CYP3A4 P08684 1/20 0.31
TMEM97 Q5BJF2 1/20 0.31
ABCG2 Q9UNQ0 1/20 0.31
P2RX7 Q99572 1/20 0.30
HCRTR1 O43613 4/20 0.30
KCNE1 P15382 1/20 0.30
CCR1 P32246 1/20 0.30
KCNQ1 P51787 1/20 0.30
CNR2 P34972 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5532198 0.89 CYP2C9 (0.36) CYP2C9KCNH2KCNK3SLC22A2CYP3A4
SCHEMBL14510810 0.87 CYP2C9 (0.35) CYP2C9KCNH2KCNK3EGLN1DDR1
SCHEMBL5536690 0.87 CYP2C9 (0.40) CYP2C9KCNH2KCNK3SLC22A2CYP3A4
SCHEMBL2524286 0.87 CYP2C9 (0.35) CYP2C9KCNH2KCNK3EGLN1DDR1
SCHEMBL4826941 0.86 CYP2C9 (0.34) CYP2C9KCNH2KCNK3EGLN1HCRTR1
SCHEMBL2529047 0.86 CYP2C9 (0.35) CYP2C9KCNH2KCNK3EGLN1CNR1
SCHEMBL2530121 0.86 CYP2C9 (0.35) CYP2C9KCNH2KCNK3EGLN1CNR1
SCHEMBL4825040 0.85 CYP2C9 (0.35) CYP2C9KCNH2KCNK3HCRTR1
SCHEMBL4830966 0.85 CYP2C9 (0.35) CYP2C9KCNH2KCNK3HCRTR1
SCHEMBL2527447 0.84 CYP2C9 (0.35) CYP2C9KCNH2KCNK3EGLN1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1948666-A1 HIV INTEGRASE INHIBITORS Bristol-Myers Squibb Company (US) 2008-07-30 EP claimed
WO-2007061714-A1 HIV INTEGRASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2007-05-31 WO claimed