Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 7/20 | 0.77 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.31 |
| ▸ | PARP1 | P09874 | 4/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695826 | 1.00 | PDE9A (0.77) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6692160 | 0.87 | PDE9A (0.58) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6695628 | 0.85 | PDE9A (0.57) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6689237 | 0.85 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6686774 | 0.85 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6758950 | 0.85 | PDE9A (0.56) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6763582 | 0.84 | PDE9A (0.55) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6875142 | 0.84 | PDE9A (0.55) | PDE9APDE1CPDE5APDE1APDE1B | |
| SCHEMBL6694674 | 0.84 | PDE9A (0.55) | PDE9APDE1CPDE5APDE1APDE1B | |
| Hydrochloric Acid SCHEMBL6756687 | 0.83 | PDE9A (0.54) | PDE9APDE1CPDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080282364-A1 | Phosphodiesterase 9 Inhibition as Treatment for Obesity-Related Conditions | BLACK SHAWN C | 2008-11-13 | — | — | US | disclosed |
| EP-1686998-A1 | PHOSPHODIESTERASE 9 INHIBITION AS TREATMENT FOR OBESITY-RELATED CONDITIONS | Pfizer Products Inc. (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005041972-A1 | PHOSPHODIESTERASE 9 INHIBITION AS TREATMENT FOR OBESITY-RELATED CONDITIONS | PFIZER PRODUCTS INC. (US) | 2005-05-12 | — | — | WO | disclosed |