Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 18/20 | 0.86 |
| ▸ | AKT2 | P31751 | 18/20 | 0.86 |
| ▸ | GSK3B | P49841 | 18/20 | 0.86 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596235 | 0.94 | AKT1 (0.86) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4596246 | 0.93 | AKT1 (0.86) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4595913 | 0.93 | AKT1 (1.00) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4596238 | 0.93 | AKT1 (1.00) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4595709 | 0.93 | AKT1 (1.00) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4595729 | 0.92 | AKT1 (0.85) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4594855 | 0.90 | AKT1 (0.79) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4594586 | 0.89 | AKT1 (0.82) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4596263 | 0.89 | AKT1 (0.86) | AKT1AKT2GSK3BAKT3 | |
| SCHEMBL4596176 | 0.88 | AKT1 (0.92) | AKT1AKT2GSK3BAKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | claimed |
| US-20080318947-A1 | Inhibitors of Akt Activity | HEERDING DIRK A | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318947-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | AKT1 5/4885AKT2 3/4885GSK3B 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.