Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.41 |
| ▸ | AKT1 | P31749 | 5/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 5/20 | 0.41 |
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.37 |
| ▸ | PRKACA | P17612 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5066166 | 0.91 | AKT1 (0.37) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5066235 | 0.89 | AKT1 (0.46) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5058475 | 0.86 | SLC2A1 (0.38) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5058418 | 0.84 | AKT1 (0.47) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5067601 | 0.84 | SLC2A1 (0.37) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5058479 | 0.80 | AKT1 (0.49) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5066120 | 0.78 | AKT1 (0.67) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| SCHEMBL5067603 | 0.77 | RPS6KA5 (0.35) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| Trifluoroacetic Acid SCHEMBL5066431 | 0.77 | AKT1 (0.65) | ROCK1AKT1RPS6KA1AKT2SLC2A1 | |
| SCHEMBL5058420 | 0.76 | AKT1 (0.42) | ROCK1AKT1RPS6KA1AKT2SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | ROCK1 478/4885AKT1 5/4885RPS6KA1 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.