SCHEMBL506684 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ATR	Q13535	15/20	0.37

▸	PPARA	Q07869	1/20	0.37

▸	ATM	Q13315	5/20	0.36

▸	PRKDC	P78527	3/20	0.35

▸	GSK3B	P49841	2/20	0.35

▸	JAK2	O60674	1/20	0.35

▸	ABL1	P00519	1/20	0.35

▸	KIT	P10721	1/20	0.35

▸	SERPINA2	P20848	1/20	0.35

▸	PIK3R1	P27986	1/20	0.35

▸	FLT4	P35916	1/20	0.35

▸	FLT3	P36888	1/20	0.35

▸	PIK3CA	P42336	1/20	0.35

▸	MTOR	P42345	1/20	0.35

▸	SYK	P43405	1/20	0.35

▸	GSK3A	P49840	1/20	0.35

▸	MAP3K9	P80192	1/20	0.35

▸	KCNH2	Q12809	1/20	0.35

▸	MERTK	Q12866	1/20	0.35

▸	DYRK2	Q92630	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30275257	1.00	ATR (0.37)	ATRPPARAATMPRKDCGSK3B
SCHEMBL506966	0.92	ATR (0.36)	ATRPPARAATMPRKDCGSK3B
SCHEMBL14865808	0.91	ACVR1 (0.37)	ATRPPARAATMPRKDCGSK3B
SCHEMBL506782	0.91	ATR (0.36)	ATRPPARAATMPRKDCGSK3B
SCHEMBL14829302	0.90	PPARA (0.37)	ATRPPARAATMPRKDCGSK3B
SCHEMBL30275224	0.90	PPARA (0.37)	ATRPPARAATMPRKDCGSK3B
SCHEMBL506451	0.90	PPARA (0.40)	ATRPPARAATMPRKDCGSK3B
SCHEMBL15105510	0.89	PPARA (0.38)	ATRPPARAATMPRKDCGSK3B
SCHEMBL30275172	0.89	PPARA (0.38)	ATRPPARAATMPRKDCGSK3B
SCHEMBL30275196	0.89	PPARA (0.38)	ATRPPARAATMPRKDCGSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023016525-A1	COMPOUND AS ATR KINASE INHIBITOR	苏州爱科百发生物医药技术有限公司	2023-02-16	—	—	WO	disclosed
US-9630956-B2	Compounds useful as inhibitors of ATR kinase	VERTEX PHARMACEUTICALS INCORPORATED (US)	2017-04-25	—	—	US	disclosed
US-9630956-B2	Compounds useful as inhibitors of ATR kinase	VERTEX PHARMACEUTICALS INCORPORATED (US)	2017-04-25	—	—	US	disclosed
US-9630956-B2	Compounds useful as inhibitors of ATR kinase	VERTEX PHARMACEUTICALS INCORPORATED (US)	2017-04-25	—	—	US	disclosed
EP-2569313-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	Vertex Pharmaceuticals Incorporated (US)	2013-03-20	—	—	EP	disclosed
US-20120027874-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	VERTEX PHARMACEUTICALS INCORPORATED (US)	2012-02-02	—	—	US	disclosed
US-20120027874-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	VERTEX PHARMACEUTICALS INCORPORATED (US)	2012-02-02	—	—	US	disclosed
US-20120027874-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	VERTEX PHARMACEUTICALS INCORPORATED (US)	2012-02-02	—	—	US	disclosed
WO-2011143426-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	VERTEX PHARMACEUTICALS INCORPORATED (US)	2011-11-17	—	—	WO	disclosed
WO-2011143426-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	VERTEX PHARMACEUTICALS INCORPORATED (US)	2011-11-17	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120027874-A1	COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE	ATR, CHEK1, CHEK2	ATR 1/4885PPARA 3722/4885ATM 32/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.